跳到主要內容區

專任教師

  • 職稱
    特聘教授
  • 姓名
    花國鋒
  • 電子郵件
  • 聯絡電話
    (03)9357400#7626
  • 授課領域
    分子免疫學; 生技產學合作交流講座; 生物化學實驗; 生物技術研究法; 生物技術特論; 生物技術與動物科學專論; 生物技術與動物科學導論; 抗發炎分析平台與應用; 抗發炎活性分析平台與應用; 保健產品之分子免疫評估方法; 保健產品專題討論; 畜牧資源於健康及環境的精準再利用; 神經保護製劑與抗癌藥物開發; 高等分子生物學; 高等分子免疫學; 高等生物技術; 動物科技特論; 基因體操作技術; 細胞訊息傳遞; 發炎體與疾病; 精準生物製劑於動物健康管理之應用; 醣生物學特論
  • 研究專長
    多醣免疫調節活性分析; 天然物抗發炎活性分析; 合成藥物抗癌活性分析; NLRP3 inflammasome
學校 主修 學位 國別
國立陽明大學 醫學生物技術研究所 博士 中華民國
輔仁大學 生物系 學士 中華民國
服務機關 服務部門 職稱 起訖年月
Frontiers in Immunology Frontiers in Immunology Associate Editor 2022.03~
國立宜蘭大學 國際產學聯盟 辦公室主任 2021.08~2022.07
國立宜蘭大學 生物技術與動物科學系 系主任 2021.08~
國立宜蘭大學 研究發展處 研發長 2020.02~2021.07
International Journal of Molecular Sciences Special Issue: Inflammasome Guest Editor 2019.09~
Scientific Reports Scientific Reports Editor 2019.06~
國立宜蘭大學 生物技術與動物科學系 特聘教授 2018.08~
日本 University of Tsukuba Faculty of Medicine 訪問學者 2016
國立宜蘭大學 生物技術與動物科學系 教授 2015.08~2018.07
英國 The John Innes Centre Department of Biological Chemistry 訪問學者 2014
國立宜蘭大學 生物技術與動物科學系 副教授 2012.08~2015.07
國立宜蘭大學 生物技術研究所 副教授 2011.08~2012.07
國立宜蘭大學 生物技術研究所 助理教授 2009.08~2011.07
中國醫藥大學 藥物安全研究所 助理教授 2008.08~2009.07
類別 獲獎日期 名稱 國別 頒獎單位 獎助金額
校內 2023/10/20 112年度國科會大專校院研究獎勵 中華民國 研發處 157200
校內 2022/10/16 111年度國科會大專校院研究獎勵 中華民國 研發處 158400
校內 2021/11/09 110年度研究績優獎 中華民國 研發處 80000
校內 2021/10/18 110年度科技部大專校院研究獎勵 中華民國 科技部 160800
校內 2020/07/28 109年度科技部大專校院研究獎勵 中華民國 科技部 154800
校內 2020/04/24 109年度產學合作績優教師 中華民國 研發處 50000
校內 2019/08/08 108年度科技部大專校院研究獎勵 中華民國 科技部 114000
校內 2018/08/14 107年度科技部大專校院研究獎勵 中華民國 科技部 106800
校內 2017/12/06 106年度研究績優獎 中華民國 研發處 80000
校內 2017/09/25 106年度大專校院獎勵特殊優秀人才 中華民國 科技部 103800
校內 2015/08/31 104年度大專校院獎勵特殊優秀人才 中華民國 科技部 120240
校內 2013/09/28 102年度研究績優獎 中華民國 國立宜蘭大學 80000
校內 2013/09/17 102學年度院級研究績優教師 中華民國 生物資源學院 12000
校內 2013/09/17 生資學院研究績優教師 中華民國 生資學院
校內 2012/07/30 101年度大專校院獎勵特殊優秀人才 中華民國 行政院國家科學委員會 134256
校內 2011/08/15 100年度大專校院獎勵特殊優秀人才 中華民國 行政院國家科學委員會 130200
實驗室名稱 實驗室網站連結
發炎反應研究室
年度 篇名 期刊等級 期刊名稱 第一作者 共同作者 卷期 起始頁 結束頁 總頁數 語言 相關網址
2024 Antcin-H, a natural triterpene derived from Antrodia cinnamomea, ameliorates dextran sulfate sodium-induced colitis in mice by inhibiting the NLRP3 inflammasome SCI Journal of Traditional and Complementary Medicine Wei-Ting Wong, Lan-Hui Li, Hsiao-Wen Chiu, Mridula P. Menon, Hsien-Ta Hsu, Wen-Yu Lin, Chun-Hsien Wu, Chen-Lung Ho, Kuo-Feng Hua in press 0 0 0
2024 Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages SCI Journal of Inflammation Kuo-Feng Hua Yu-Bei Lin, Hsiao-Wen Chiu, Wei-Ting Wong, Shuk-Man Ka, Chun-Hsien Wu, Wen-Yu Lin, Chien-Chun Wang, Chung-Hua Hsu, Hsien-Ta Hsu, Chen-Lung Ho, Lan-Hui Li in press 0 0 0
2024 Cinnamaldehyde, a bioactive compound from the leaves of Cinnamomum osmophloeum kaneh, ameliorates dextran sulfate sodium-induced colitis in mice by inhibiting the NLRP3 inflammasome SCI Journal of Physiological Investigation May-Lan Liu Wei-Ting Wong, Yih-Ming Weng, Chen-Lung Ho, Hsien-Ta Hsu, Kuo-Feng Hua, Chun-Hsien Wu, Lan-Hui Li in press 0 0 0
2024 Honokiol exhibits anti-NLRP3 inflammasome and antimicrobial properties in Neisseria gonorrhoeae-infected macrophages SCI Journal of Inflammation Research Kuo-Feng Hua Hsien-Ta Hsu, May-Shu Huang, Hsiao-Wen Chiu, Wei-Ting Wong, Chien-Hsiu Peng, Yu-Bei Lin, Ann Chen, Chien-Chun Wang, Chung-Hua Hsu, Chun-Hsien Wu, Wen-Yu Lin, Chen-Lung Ho, Lan-Hui Li in press 0 0 0
2024 Management and control of coccidiosis in poultry SCI Animal Bioscience Rafiq Ahmad Yu-Hsiang Yu, Kuo-Feng Hua, Wei-Jung Chen, Daniel Zaborski, Andrzej Dybus, Felix Shih-Hsiang Hsiao, Yeong-Hsiang Cheng 37(1) 1 15 0
2024 The angiotensin II receptor neprilysin inhibitor LCZ696 inhibits the NLRP3 inflammasome by reducing mitochondrial dysfunction in macrophages and alleviates dextran sulfate sodium-induced colitis in a mouse model SCI Inflammation Hsiao-Wen Chiu Chun-Hsien Wu, Wen-Yu Lin, Wei-Ting Wong, Wei-Che Tsai, Hsien-Ta Hsu, Chen-Lung Ho, Shu-Meng Cheng, Cheng-Chung Cheng, Shih-Ping Yang, Lan-Hui Li, Kuo-Feng Hua 47(2) 696 717 0
2023 Antrodia cinnamomea may interfere with the interaction between ACE2 and SARS-CoV-2 spike protein in vitro and reduces lung inflammation in a hamster model of COVID-19 SCI Journal of Inflammation Research Lan-Hui Li Hsiao-Wen Chiu, Wei-Ting Wong, Ko-Chieh Huang, Tzu-Wen Lin, Shui-Tein Chen, Kuo-Feng Hua 16 4867 4884 0
2023 Daylily (Hemerocallis fulva Linn.) flowers improve sleep quality in human and reduce nitric oxide and interleukin-6 production in macrophages SCI Chinese Journal of Physiology Li-Min Hsu Hua-Wei Chen, Po-Ching Wu, Kuo-Feng Hua 66 313 325 0
2023 Editorial: Novel perspectives on the NLRP3 inflammasome SCI Frontiers in Immunology Ying Liang Kuo-Feng Hua 14 1211385 0 0
2023 Feasibility study of value-added production from onion peel agricultural wastes for circular economy SCI Journal of the Taiwan Institute of Chemical Engineers Chung-Chuan Hsueh Timothy Jen Roxas, Yu-Hsuan Chan, Ching-Ning Juan, Lemmuel Lara Tayo, Ya-Yun Chen, Yun-Chen Wu, Kuo-Fen Hua, Po-Wei Tsai, Shu-Yun Sun, Bor-Yann Chen 145 104851 0 0
2023 Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells SCI Journal of Inflammation Research Kuo-Feng Hua Lan-Hui Li, Hsin-Chiao Yu, Wei-Ting Wong, Hsien-Ta Hsu 16 5235 5248 0
2023 Pushing the Boundaries of Structural Heterogeneity with the Lipid A of Marine Bacteria Cellulophaga SCI Chembiochem Roberta Cirella Chiara Pagliuca, Molly Dorothy Pither, Elena Scaglione, Olga I Nedashkovskaya, Oleg V Chernikov, Kuo-Feng Hua, Roberta Colicchio, Mariateresa Vitiello, Maxim S Kokoulin, Alba Silipo, Paola Salvatore, Antonio Molinaro, Flaviana Di Lorenzo 24(10) 0 0
2022 A selective inhibitor of the NLRP3 inflammasome as a potential therapeutic approach for neuroprotection in a transgenic mouse model of Huntington’s disease SCI Journal of Neuroinflammation Kai-Po Chen Kuo-Feng Hua, Fu-Ting Tsai, Ting-Yu Lin, Chih-Yuan Cheng, Ding-I Yang, Hsien-Ta Hsu, Tz-Chuen Ju 19(1) 56 0 0
2022 An Immunological Polysaccharide from Tremella fuciformis: Essential of Acetylation in Immunomodulation SCI International Journal of Molecular Sciences Tzu-Yin Huang Feng-Ling Yang, Hsiao-Wen Chiu, Hong-Chu Chao, Yen-Ju Yang, Jyh-Horng Sheu, Kuo-Feng Hua, Shih-Hsiung Wu 23(18) 10392 0 0
2022 Antiinflammation derived Suzuki-coupled fenbufens as COX-2 inhibitors: minilibrary construction and bioassay SCI Molecules Shiou-Shiow Farn Yen-Buo Lai, Kuo-Fong Hua, Hsiang-Ping Chen, Tzu-Yi Yu, Sheng-Nan Lo, Li-Hsin Shen, Rong-Jiun Sheu, Chung-Shan Yu 27(9) 2850 0 0
2022 Freshwater clam extract mitigates neuroinflammation and amplifies neurotrophic activity of glia: insights from in vitro model of neurodegenerative pathomechanism SCI Journal of Clinical Medicine Muh-Shi Lin Shu-Mei Chen, Kuo-Feng Hua, Wei-Jung Chen, Cho-Chen Hsieh, Chai-Ching Lin 11(3) 553 0 0
2022 Ginsenoside compound K reduces the progression of Huntington's disease via the inhibition of oxidative stress and overactivation of the ATM/AMPK pathway SCI Journal of Ginseng Research Kuo-Feng Hua A-Ching Chao, Ting-Yu Lin, Wan-Tze Chen, Yu-Chie Lee, Wan-Han Hsu, Sheau-Long Lee, Hsin-Min Wang, Ding-I. Yang, Tz-Chuen Ju 46 572 584 0
2022 Nano modification of Antrodia cinnamomea exhibits anti-inflammatory action and improves the migratory potential of myogenic progenitors SCI Cells Mridula P. Menon Yi-Hsuan Chien, Joy Thomas, Yu-Hsiang Yu, Chang-Tang Chang, Kuo-Feng Hua 11 2512 0 0
2022 Optimization of Emulsification Conditions on Ethanol Extract of Taiwanese Green Propolis Using Polysorbate and Its Immunomodulatory Effects in Broilers SCI Animals Felix Shih-Hsiang Hsiao Clara Ajeng Artdita, Kuo-Feng Hua, Chia-Jung Tsai, Yi-Hsuan Chien, Yue-Wen Chen, Yeong-Hsiang Cheng, Yu-Hsiang Yu 12(4) 446 0 0
2022 Repositioning of the angiotensin II receptor antagonist candesartan as an anti-inflammatory agent with NLRP3 inflammasome inhibitory activity SCI Frontiers in Immunology Wen-Yu Lin Lan-Hui Li, Ya-Yun Hsiao, Wei-Ting Wong, Hsiao-Wen Chiu, Hsien-Ta Hsu, Yi-Jen Peng, Chen-Lung Ho, Oleg V. Chernikov, Shu-Meng Cheng, Shih-Ping Yang, Kuo-Feng Hua 13 870627 0 0
2022 Spatial Structure of Lectin from the Mussel Mytilus trossulus: In-Sights from Molecular Modelling and Practical Proof SCI Marine Drugs Alina P. Filshtein Irina V. Chikalovets, Tatyana O. Mizgina, Pavel A. Lukyanov, Kuo-Feng Hua, Oleg V. Chernikov. 21(1) 10 0 0
2022 Surfactin containing Bacillus licheniformis-fermented products alleviate dextran sulfate sodium-induced colitis by inhibiting colonic inflammation and the NLRP3 inflammasome in mice SCI Animals Wei-Che Tsai Wei-Ting Wong, Hsien-Ta Hsu, Yeong-Hsiang Cheng, Yu-Hsiang Yu, Wei-Jung Chen, Chen-Lung Ho, Hui-Chen Hsu, Kuo-Feng Hua 12 3456 0 0
2022 The leaves of the seasoning plant Litsea cubeba inhibit the NLRP3 inflammasome and ameliorate dextran sulfate sodium-induced colitis in mice SCI Frontiers in Nutrition Wei-Ting Wong Chun-Hsien Wu, Lan-Hui Li, De-Yu Hung, Hsiao-Wen Chiu, Hsien-Ta Hsu, Chen-Lung Ho, Oleg V. Chernikov, Shu-Meng Cheng, Shih-Ping Yang, Chih-Hsin Chung, Kuo-Feng Hua, Chin-Fah Wang 9 871325 0 0
2021 A GalNAc/Gal-specific lectin modulates immune responses via Toll-like receptor 4 independently of carbohydrate-binding ability SCI Chemical Communications Shin-Tai Chen Jiahn-Haur Liao, Kai-Fa Huang, I-Ming Lee, Wei-Ting Wong, Shih-Hsiung Wu 57(50) 6209 6212 0
2021 Antibacterial and Antibiofilm Activities of Novel Antimicrobial Peptides against Multidrug-Resistant Enterotoxigenic Escherichia Coli SCI International Journal of Molecular Sciences Kang-Chi Wu Kuo-Feng Hua, Yu-Hsiang Yu, Yeong-Hsiang Cheng, Ting-Ting Cheng, Yao-Kuan Huang, Hui-Wen Chang, Wei-Jung Chen 22(8) 3926 0 0
2021 Cf-02, a novel benzamide-linked small molecule, blunts NF-κB activation and NLRP3 inflammasome assembly and improves acute onset of accelerated and lupus nephritis in mice SCI FASEB Journal Shin-Ruen Yang Kuo-Feng Hua, Chung-Yao Wu, Ann Chen, Yu-Ling Tsai, Chih-Jun Wan, Chia-Chung Lee, Jia-Feng Chan, Chih-Yu Hsieh, Yu-Juei Hsu, Chia-Chao Wu, Debabrata Mukhopadhyay, Hsu-Shan Huang, Feng-Cheng Liu 35(8) 21785 0 0
2021 Editorial: NLRP3 Inflammasome: Regulatory Mechanisms, Role in Health and Disease and Therapeutic Potential SCI Frontiers in Immunology Oleg Chernikov Jong-Seok Moon, Ann Chen, Kuo-Feng Hua 12 765199 0 4
2021 Effect of Fermented Products Produced by Bacillus licheniformis on the Growth Performance and Cecal Microbial Community of Broilers under Coccidial Challenge SCI Animals (Basel) Yeong-Hsiang Cheng Yi-Bing Horng, Wei-Jung Chen, Kuo-Feng Hua, Andrzej Dybus, Yu-Hsiang Yu 11(5) 1245 0 0
2021 Effectiveness of Bacillus licheniformis-Fermented Products and Its Derived Antimicrobial Lipopeptides in Controlling Coccidiosis in Broilers SCI Animals 2021, Yu-Hsiang Yu Chia-Min Wu, Wei-Jung Chen, Kuo-Feng Hua, Je-Ruei Liu, Yeong-Hsiang Cheng 11(12) 3576 0 0
2021 Immunomodulatory properties of polysaccharides from the coral Pseudopterogorgia Americana in macrophages SCI Cells Oleg V. Chernikov Hsiao-Wen Chiu, Lan-Hui Li, Maxim S. Kokoulin, Valentina I. Molchanova, Hsien-Ta Hsu, Chen-Lung Ho, Kuo-Feng Hua 10(12) 3531 0 0
2021 Inhibition of pro-inflammatory mediator expression in macrophages using wood vinegar from griffith's ash SCI Chinese Journal of Physiology Chen-Lung Ho Chuan-Shun Lin, Lan-Hui Li, Kuo-Feng Hua, Tz-Chuen Ju 64(5) 232 243 11
2021 LCC18, a benzamide-linked small molecule, ameliorates IgA nephropathy in mice SCI Journal of Pathology Shin-Ruen Yang Kuo-Feng Hua, Akiko Takahata, Chung-Yao Wu, Chih-Yu Hsieh, Hsiao-Wen Chiu, Cheng-Hsu Chen, Debabrata Mukhopadhyay, Yusuke Suzuki, Shuk-Man Ka, Hsu-Shan Huang, Ann Chen 253(4) 427 441 0
2021 NSC828779 alleviates renal tubulointerstitial lesions involving interleukin-36 signaling in mice SCI Cells Shin-Ruen Yang Szu-Chun Hung, Lichieh Julie Chu, Kuo-Feng Hua, Chyou-Wei Wei, I-Lin Tsai, Chih-Chin Kao, Chih-Chien Sung, Pauling Chu, Chung-Yao Wu, Ann Chen, Alexander T. H. Wu, Feng-Cheng Liu, Hsu-Shan Huang, Shuk-Man Ka 10(11) 3060 0 0
2021 The unusual lipid A structure and immunoinhibitory activity of LPS from marine bacteria Echinicola pacifica KMM 6172T and Echinicola vietnamensis KMM 6221T SCI Microorganisms Molly Dorothy Pither Giuseppe Mantova, Elena Scaglione, Chiara Pagliuca, Roberta Colicchio, Mariateresa Vitiello, Oleg V. Chernikov, Kuo-Feng Hua, Maxim S. Kokoulin, Alba Silipo, Paola Salvatore, Antonio Molinaro, Flaviana Di Lorenzo 9(12) 2552 0 0
2020 A synthetic small molecule F240B decreases NLRP3 inflammasome activation by autophagy induction SCI Frontiers in Immunology Chun-Hsien Wu Chin Heng Gan, Lan-Hui Li, Jen-Che Chang, Shin-Tai Chen, Wei-Ting Wong, Mridula P. Menon, Shu-Meng Cheng, Shih-Ping Yang, Chen-Lung Ho, Oleg V. Chernikov, Chi-Hung Lin, Yulin Lam, Kuo-Feng Hua in press 0 0 0
2020 Accelerated, severe lupus nephritis benefits from treatment with honokiol by immunoregulation and differentially regulating NF-κB/NLRP3 inflammasome and sirtuin 1/autophagy axis SCI The FASEB Journal Shin-Ruen Yang Wan-Han Hsu, Chung-Yao Wu, Hung-Sheng Shang, Feng-Cheng Liu, Ann Chen, Kuo-Feng Hua*, Shuk-Man Ka* in press 0 0 0
2020 Compound K inhibits priming and mitochondria-associated activating signals of NLRP3 inflammasome in renal tubulointerstitial lesions SCI Nephrology Dialysis Transplantation Wan-Han Hsu Kuo-Feng Hua, Li-Heng Tuan, Yu-Ling Tsai, Lichieh Julie Chu, Yu-Chieh Lee, Wei-Ting Wong, Sheau-Long Lee, Jenn-Haung Lai, Ching-Liang Chu, Ling-Jun Ho, Hsiao-Wen Chiu, Yu-Juei Hsu, Shuk-Man Ka, Ann Chen 35(1) 74 85
2020 Critical role for the NLRP3 inflammasome in mediating IL-1β production in Shigella sonnei-infected macrophages SCI Frontiers in Immunology Lan-Hui Li Tzu-Ling Chen, Hsiao-Wen Chiu, Chung-Hua Hsu, Chien-Chun Wang, Tzu-Ting Tai, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, Wen-Chiuan Tsai, Kuo-Feng Hua 11 1115 0 0
2020 Eucalyptus essential oils inhibit the lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages through reducing MAPK and NF-κB pathways SCI BMC Complementary Medicine and Therapies Chen-Lung Ho Lan-Hui Li, Yueh-Chun Weng, Kuo-Feng Hua, Tz-Chuen Ju 20 200 0 0
2020 Ginsenoside M1 Induces Apoptosis and Inhibits the Migration of Human Oral Cancer Cells SCI International Journal of Molecular Sciences Yu-Chieh Lee Wei-Ting Wong, Lan-Hui Li, Lichieh Julie Chu, Mridula P. Menon, Chen-Lung Ho, Oleg V. Chernikov, Sheau-Long Lee, Kuo-Feng Hua 21 9704 0 0
2020 H-Phosphonate Synthesis and Biological Evaluation of an Immuno-modulatory Phosphoglycolipid from Thermophilic Bacteria SCI Organic Letters Chin Heng Gan Wijaya Hadhi, Lan-Hui Li, Chih-Feng Wei, Yi-Jen Peng, Shih-Hsiung Wu, Kuo-Feng Hua, Yulin Lam 22(7) 2569 2573 0
2020 IgA nephropathy benefits from compound K treatment by inhibiting NF-κB/NLRP3 inflammasome and enhancing autophagy and SIRT1 SCI Journal of Immunology Chung-Yao Wu Kuo-Feng Hua, Wan-Han Hsu, Yusuke Suzuki, Lichieh Julie Chu, Yu-Chieh Lee, Akiko Takahata, Sheau-Long Lee, Chia-Chao Wu, David J. Nikolic-Paterson, Shuk-Man Ka, Ann Chen 205(1) 202 212 0
2020 Phagocytosis enhancement, endotoxin tolerance, and signal mechanisms of immunologically active glucuronoxylomannan from Auricularia auricula-judae SCI International Journal of Biological Macromolecules Namal Perera Feng-Ling Yang, Hsiao-Wen Chiu, Chih-Yu Hsieh, Lan-Hui Li, Yan-Long Zhang, Kuo-Feng Hua, Shih-Hsiung Wu in press 0 0 0
2020 Synthetic 4-hydroxy auxarconjugatin B, a novel autophagy inducer, attenuates gouty inflammation by inhibiting the NLRP3 inflammasome SCI Cells Chih-Yu Hsieh Lan-Hui Li, Yulin Lam, Zhanxiong Fang, Chin Heng Gan, Yerra Koteswara Rao, Hsiao-Wen Chiu, Wei-Ting Wong, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, May-Lan Liu, Chung-Hua Hsu, Kuo-Feng Hua 9 279 0 0
2020 The long non-coding RNAs: paramount regulators of the NLRP3 inflammasome SCI Frontiers in Immunology Mridula Prakash Menon Kuo-Feng Hua in press 0 0 0
2020 Tris DBA Ameliorates Accelerated and Severe Lupus Nephritis in Mice by Activating Regulatory T Cells and Autophagy and Inhibiting the NLRP3 Inflammasome SCI Journal of Immunology Chung-Yao Wu Kuo-Feng Hua, Ching-Liang Chu, Shin-Ruen Yang, Jack L. Arbiser, Sung-Sen Yang, Yu-Chuan Lin, Feng-Cheng Liu, Shun-Min Yang, Shuk-Man Ka, Chen Ann 204(6) 1448 1461 13
2020 Tris DBA ameliorates IgA nephropathy by blunting the activating signal of NLRP3 inflammasome through SIRT1- and SIRT3-mediated autophagy induction SCI Journal of Cellular and Molecular Medicine Chung-Yao Wu Kuo-Feng Hua, Shin-Ruen Yang, Yi-Shan Tsai, Chih-Yu Hsieh, Chia-Chao Wu, Jia-Feng Chang, Jack L. Arbiser, Chiz-Tzung Chang, Ann Chen*, Shuk-Man Ka*. in press 0 0 0
2020 Xenon blunts NF-κB/NLRP3 inflammasome activation and improves acute onset of accelerated and severe lupus nephritis in mice SCI Kidney International Shin-Ruen Yang Kuo-Feng Hua, Lichieh Julie Chu, Yeu-Kuang Hwu, Shun-Min Yang, Chung-Yao Wu, Tsai-Jung Lin, Jui-Chun Weng, Hailin Zhao, Wan-Han Hsu, Feng-Cheng Liu, Wen-Jinn Liaw, Daqing Ma, Shuk-Man Ka, Ann Chen 1 0 0 0
2019 Accelerated and severe lupus nephritis benefits from M1, an active metabolite of ginsenoside, by regulating NLRP3 inflammasome and T cell functions in mice SCI Frontiers in Immunology Tsai-Jung Lin Chung-Yao Wu, Pei-Yi Tsai, Wan-Han Hsu, Kuo-Feng Hua, Ching-Liang Chu, Yu-Chieh Lee, Ann Chen, Sheau-Long Lee, Yi-Jin Lin, Chih-Yu Hsieh, Shin-Ruen Yang, Feng-Cheng Liu, Shuk-Man Ka 10 1951 0 0
2019 Activity Dependence of a Novel Lectin Family on Structure and Carbohydrate-Binding Properties SCI Molecules Irina Chikalovets Alina Filshtein, Valentina Molchanova, Tatyana Mizgina, Pavel Lukyanov, Olga Nedashkovskaya, Kuo-Feng Hua, Oleg Chernikov 25(1) 150 0 0
2019 Bacillus licheniformis-Fermented Products Reduce Diarrhea Incidence and Alter the Fecal Microbiota Community in Weaning Piglets SCI Animals De-Yu Hung Yeong-Hsiang Cheng, Wei-Jung Chen, Kuo-Feng Hua, Arkadiusz Pietruszka, Andrzej Dybus, Chuan-Shun Lin, Yu-Hsiang Yu 9 1145 0 0
2019 Glucosamine inhibits IL-1β expression by preserving mitochondrial integrity and disrupting assembly of the NLRP3 inflammasome. SCI Scientific Reports Hsiao-Wen Chiu Lan-Hui Li, Chih-Yu Hsieh, Yerra Koteswara Rao, Fang-Hsin Chen, Ann Chen, Shuk-Man Ka, Kuo-Feng Hua 9(1) 5603 0 0
2019 Mechanistic insight into the activation of the NLRP3 inflammasome by Neisseria gonorrhoeae in macrophages SCI Frontiers in Immunology Lan-Hui Li Jia-Sing Lin, Hsiao-Wen Chiu, Wen-Yu Lin, Tz-Chuen Ju, Fang-Hsin Chen, Oleg V. Chernikov, May-Lan Liu, Jen-Che Chang, Chung-Hua Hsu, Ann Chen, Shuk-Man Ka, Hong-Wei Gao, Kuo-Feng Hua 10 1815 0 0
2019 Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome SCI Journal of Cellular Physiology Chih-Yu Hsieh Lan-Hui Li, Yerra Koteswara Rao, Tz-Chuen Ju, Yu-Shin Nai, Yue-Wen Chen, Kuo-Feng Hua 234(4) 4081 4094 13
2019 Synthesis of the trisaccharide repeating unit of capsular polysaccharide from Klebsiella pneumonia SCI Tetrahedron Letters Woen Susanto Kah-Hoe Kong, Kuo-Feng Hua, Shih-Hsiung Wu, Yulin Lam 60(3) 288 291 3
2018 Affinity-driven Covalent Modulator of Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Cascade SCI Angewandte Chemie International Edition in English Jeffy Chern Chun-Ping Lu, Zhanxiong Fang, Ching-Ming Chang, Kuo-Feng Hua, Yi-Ting Chen, Cheng Yang Ng, Yi-Lin Sophia Chen, Yulin Lam, Shih-Hsiung Wu 57(24) 7040 7045 5
2018 Antrodia cinnamomea Galactomannan Elicits Immunostimulatory Activity Through Toll-like receptor 4 SCI International Journal of Biological Sciences Namal Perera Feng-Ling Yang, Yueh-Tung Lu, Lan-Hui Li, Kuo-Feng Hua, Shih-Hsiung Wu 14(10) 1378 1388 10
2018 Carboxylic and O-acetyl moieties are essential for the immunostimulatory activity of glucuronoxylomannan: a novel TLR4 specific immunostimulator from Auricularia auricula-judae SCI Chemical Communications Namal Perera Feng-Ling Yang, Jeffy Chern, Hsiao-Wen Chiu, Chih-Yu Hsieh, Lan-Hui Li, Yan-Long Zhang, Kuo-Feng Hua, Shih-Hsiung Wu 54(51) 6995 6998 3
2018 Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells. SCI Scientific Reports Han-Ying Wu Feng-Ling Yang, Lan-Hui Li, Yerra Koteswara Rao, Tz-Chuen Ju, Wei-Ting Wong, Chih-Yu Hsieh, Michael V. Pivkin, Kuo-Feng Hua, Shih-Hsiung Wu 8(1) 17956 0 0
2018 Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin SCI Chemico-Biological Interactions Chun-Ping Lu Chien-Yu Huang, Szu-Hsuan Wang, Chih-Hsien Chiu, Lan-Hui Li, Kuo-Feng Hua, Tzu-Hua Wu 290 12 18 6
2018 Repositioning of the β-blocker carvedilol as a novel autophagy inducer that inhibits the NLRP3 inflammasome SCI Frontiers in Immunology Wei-Ting Wong Lan-Hui Li, Yerra Koteswara Rao, Shih-Ping Yang, Shu-Meng Cheng, Wen-Yu Lin, Cheng-Chung Cheng, Ann Chen, Kuo-Feng Hua 9 1920 0 0
2013 Antroquinonol mitigates accelerated and progressive IgA nephropathy model in mice via activating NrF2 pathway, and inhibiting T cells and NLRP3 inflammasome SCI Free Radic Biol Med,61C 花國鋒 Shun-Min Yang, Shuk-Man Ka, Kuo-Feng Hua, Tzu-Hua Wu, Yi-Ping Chuang, Ya-Wen Lin, Feng-Ling Yang, Shih-Hsiung Wu, Sung-Sen Yang, Shih-Hua Lin, Jia-Ming Chang, Ann Chen 285 297
2013 Bamboo vinegar decreases inflammatory mediator expression and NLRP3 inflammasome activation by inhibiting reactive oxygen species generation and protein kinase C-alpha/delta activation SCI PLoS ONE 花國鋒 Chen-Lung Ho, Chai-Yi Lin, Shuk-Man Ka, Ann Chen, Yu-Ling Tasi, May-Lan Liu, Yi-Chich Chiu, Kuo-Feng Hua vol. 8, no. 10
2013 Citral is renoprotective for focal segmental glomerulosclerosis by inhibiting oxidative stress and apoptosis and activating Nrf2 pathway in mice. SCI PLoS ONE 花國鋒 Shun-Min Yang, Kuo-Feng Hua, Yu-Chuan Lin, Ann Chen, Jia-Ming Chang, Louis Kuoping Chao, Chen-Lung Ho, Shuk-Man Ka vol. 8, no. 9
2013 Generation of reactive oxygen species by polyenylpyrroles derivatives causes DNA damage leading to G2/M arrest and apoptosis in human oral squamous cell carcinoma cells SCI PLoS ONE 花國鋒 Kuo-Feng Hua, Pei-Chun Liao, Zhanxiong Fang, Feng-Ling Yang, Yu-Liang Yang, Yi-Lin Chen, Yi-Chich Chiu, May-Lan Liu, Yulin Lam, Shih-Hsiung Wu vol. 8, no. 6
2013 Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1β secretion SCI Inflammation Research 花國鋒 Pei-Chun Liao, Louis Kuoping Chao, Ju-Ching Chou, Wei-Chih Dong, Chien-Nan Lin, Chai-Yi Lin, Ann Chen, Shuk-Man Ka, Chen-Lung Ho, Kuo-Feng Hua vol.62,no.1 89 96
2013 Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-kB/NLRP3 pathway SCI PLoS ONE 花國鋒 Kuo-Feng Hua, Shun-Min Yang, Tzu-Yang Kao, Jia-Ming Chang, Hui-Ling Chen, Sung-Sen Yang, Louis Kuoping Chao, Ann Chen, Shuk-Man Ka
2013 Polyenylpyrrole derivatives inhibit NLRP3 inflammasome activation and inflammatory mediator expression through reduction of reactive oxygen species production and mitogen-activated protein kinase activation SCI PLoS ONE 花國鋒 Kuo-Feng Hua, Ju-Ching Chou, Yulin Lam, Yu-Ling Tasi, Ann Chen, Shuk-Man Ka, Zhanxiong Fang, May-Lan Liu, Feng-Ling Yang, Yu-Liang Yang, Yi-Chich Chiu, Shih-Hsiung Wu vol. 8, no. 10
2012 Composition and Antipathogenic Activities of the Twig Essential Oil of Chamaecyparis formosensis from Taiwan SCI Natural Product Communications 花國鋒 Chen-Lung Ho, Kuo-Feng Hua, Kuan-Ping Hsu, Eugene I-Chen Wang, Yu-Chang Su vol.7,no7 933 936
2012 Freshwater Clam Extract Inhibits Inflammatory Responses in LPS-activated Macrophages by Reducing the Activation of Mitogen-activated Protein Kinases and NF-κB SCI Natural Product Communications 花國鋒 Kuo-Feng Hua, Guan-Ming Chen, Chen-Lung Hob, Ming-Chung Chena, Yi-Ling Chena, Wei-Jung Chena, Jeng-Fang Huangc, Yuan-Shing Perngd, Chai-Ching Lin vol.7,no.11 1435 1440
2012 High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-alpha/delta and NF-kB SCI Inflammation Research 花國鋒 Kuo-Feng Hua, Szu-Hsuan Wang, Wei-Chih Dong, Chai-Yi Lin, Chen-Lung Ho, Tzu-Hua Wu vol.61,no10 1107 1116
2012 Oligosaccharide and Peptidoglycan of Ganoderma lucidum Activate the Immune Response in Human Mononuclear Cells SCI Journal of Agricultural and Food Chemistry 花國鋒 Chia-Che Tsai, Feng-Ling Yang, Zih-You Huang, Chien-Sheng Chen, Yu-Liang Yang, Kuo-Feng Hua, Jianjun Li, Shui-Tein Chen, and Shih-Hsiung Wu vol.60,no11 2830 2837
2011 A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the immune response through Toll-like receptor 2 SCI Journal of Biological Chemistry 花國鋒 Miao-Hsia Lin, Yu-Liang Yang, Yen-Po Chen, Kuo-Feng Hua, Chun-Ping Lu, Fuu Sheu, Guang-Huey Lin, San-San Tsay, Shu-Mei Liang, Shih-Hsiung Wu vol.286,no20 17736 17745
2011 Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation SCI Free Radical Biology & Medicine 花國鋒 Pei-Yi Tsai, Shuk-Man Ka, Jia-Ming Chang, Hsiang-Cheng Chen, Hao-Ai Shui, Chen-Yun Li, Kuo-Feng Hua, Wen-Liang Chang, Jiann-Jyh Huang, Sung-Sen Yang, Ann Chen vol.51,no3 744 754
2011 Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells SCI Journal of Cellular Physiology 花國鋒 Chia-Yang Li, Louis Kuoping Chao, Shu-Chi Wang, Min-Lung Tsai, Hon-Zu Chang, Shih-Hua Fang, Pei-Chun Liao, Chen-Lung Ho, Shui-Tein Chen, Wei-Chung Cheng, Chi-Shiun Chiang, Yueh-Hsiung Kuo, Kuo-Feng Hua, Ian C. Hsu vol.262,no9 2338 2349
2011 Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4 SCI Journal of Biological Chemistry 花國鋒 Feng-Ling Yang, Yu-Liang Yang, Pei-Chun Liao, Ju-Ching Chou, Keng-Chang Tsai, An-Suei Yang, Fuu Sheu, Tzu-Lung Lin, Pei-Fang Hsieh, Jin-Town Wang, Kuo-Feng Hua, Shih-Hsiung Wu vol.286,no24 21041 21051
2010 Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kB pathway to reduce LPS-induced TNF-alpha and NO expression SCI Journal of Agricultural and Food Chemistry 花國鋒 Louis Kuoping Chao, Pei-Chun Liao, Chen-Lung Ho, Eugene I-Chen Wang, Chao-Chin Chuang, Huan-Wen Chiu, Lang-Bang Hung, Kuo-Feng Hua vol.58,no.6 3472 3478
2010 Binding and cleavage of E. coli Hua by the E. SCI coli Lon,Biophysical Journal 花國鋒 Jiahn-Haur Liao, Yu-Ching Lin, Jowey Hsu, Alan Yueh-Luen Lee, Tse-An Chen, Chun-Hua Hsu, Jiun-Ly Chir, Kuo-Feng Hua, Tzu-Hua Wu, Li-Jenn Hong, Pei-Wen Yen, Arthur Chiou, Shih-Hsiung Wu vol.98,no.1 129 137
2010 Immunostimulatory bioactivity of algal polysaccharides from Chlorella pyrenoidosa activates macrophages via Toll-like receptor 4 SCI Journal of Agricultural and Food Chemistry 花國鋒 Hsien-Yeh Hsu, Narumon Jeyashoke, Chin-His Yeh, Yuan-Jaw Song, Kuo-Feng Hua, Louis Kuoping Chao vol.58,no.2 927 936
2010 Osthole regulates inflammatory mediator expression through modulating NF-kB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species SCI Journal of Agricultural and Food Chemistry 花國鋒 Pei-Chun Liao, Shin-Chang Chien, Chen-Lung Ho, Eugene I-Chen Wang, Shu-Ching Lee, Yueh-Hsiung Kuo, Narumon Jeyashoke, Jie Chen, Wei-Chih Dong, Louis Kuoping Chao, Kuo-Feng Hua vol.58,no19 10445 10451
2010 Synthesis and biological evaluation of polyenylpyrrole derivatives as anti-cancer agents acting through caspases-dependent apoptosis SCI Journal of Medicinal Chemistry 花國鋒 Zhanxiong Fang, Pei-Chun Liao, Yu-Liang Yang, Feng-Ling Yang, Yi-Ling Chen, Yulin Lam*, Kuo-Feng Hua, Shih-Hsiung Wu vol.53,no22 7967 7978
西元年度 計畫名稱 主持人 工作職稱 共同(協同)主持人 委託/補助機構 計畫開始日 計畫結束日 語言 相關網址
2024 探討台灣綠蜂膠產品於抗發炎和代謝調節之功效與分子機制及其在健康照護與動物產業的應用-台灣綠蜂膠預防與改善NLRP3發炎體相關疾病之效果與作用機轉(2/3) 花國鋒 主持人 國科會 2024/08/01 2025/07/31
2024 開發山胡椒成為預防與改善NLRP3發炎體相關疾病之營養保健品(3/3) 花國鋒 主持人 科技部 2024/08/01 2025/07/31
2023 探討台灣綠蜂膠產品於抗發炎和代謝調節之功效與分子機制及其在健康照護與動物產業的應用-台灣綠蜂膠預防與改善NLRP3發炎體相關疾病之效果與作用機轉(1/3) 花國鋒 主持人 國家科學及技術委員會 2023/08/01 2024/07/31
2023 臺俄(RU)雙邊協議型擴充加值(add-on)國際合作研究計畫-開發具免疫調節活性之海洋天然物(3/3) 花國鋒 主持人 科技部 2023/01/01 2023/12/31
2023 開發山胡椒成為預防與改善NLRP3發炎體相關疾病之營養保健品(2/3) 花國鋒 主持人 科技部 2023/08/01 2024/07/31
2022 探討地衣芽孢桿菌對鴨隻免疫性狀與腸道絨毛性狀的影響 鄭永祥 協同主持人 蘇晉暉、游玉祥、陳威戎、花國鋒 行政院農業委員會畜產試驗所宜蘭分所 2022/01/01 2022/12/31
2022 臺俄(RU)雙邊協議型擴充加值(add-on)國際合作研究計畫-開發具免疫調節活性之海洋天然物(2/3) 花國鋒 主持人 科技部 2022/01/01 2022/12/31
2022 開發山胡椒成為預防與改善NLRP3發炎體相關疾病之營養保健品(1/3) 花國鋒 主持人 科技部 2022/08/01 2023/07/31
2021 探討肉桂醛與肉桂醛衍生物用於調節NLRP3發炎體及改善發炎性腸道疾病及痛風性發炎之功效與作用機轉(3/3) 花國鋒 主持人 科技部 2021/08/01 2022/07/31
2021 東台灣農村再生漁業多元化地方經濟樞紐輔導團計畫 吳柏青 協同主持人 陳威戎、鄔家琪、王進發、張介仁、花國鋒 行政院農業委員會 2021/01/01 2021/12/31
2021 臺俄(RU)雙邊協議型擴充加值(add-on)國際合作研究計畫-開發具免疫調節活性之海洋天然物(1/3) 花國鋒 主持人 科技部 2021/01/01 2021/12/31
2020 地衣桿菌產製抗菌肽於禽畜及伴侶動物之保健機轉驗證與轉譯研發-地衣桿菌產製抗菌肽於禽畜及伴侶動物之保健機轉驗證與轉譯研發 鄭永祥 共同主持人 武敬和、花國鋒、游玉祥 科技部 2020/08/01 2021/07/31
2020 探討肉桂醛與肉桂醛衍生物用於調節NLRP3發炎體及改善發炎性腸道疾病及痛風性發炎之功效與作用機轉(2/3) 花國鋒 主持人 - 科技部 2020/08/01 2021/07/31
2020 東台灣農村再生漁業多元化地方經濟樞紐輔導團計畫 吳柏青 協同主持人 陳威戎、鄔家琪、王進發、張介仁、花國鋒 行政院農業委員會 2020/07/01 2020/12/31
2020 浩峰一號對亨廷頓舞蹈症小鼠之影響 花國鋒 主持人 浩峰生物科技股份有限公司 2020/04/01 2021/03/31
2020 浩峰一號對腸道發炎疾病小鼠之影響 花國鋒 主持人 浩峰生物科技股份有限公司 2020/04/01 2021/03/31
2019 探討肉桂醛與肉桂醛衍生物用於調節NLRP3發炎體及改善發炎性腸道疾病及痛風性發炎之功效與作用機轉(1/3) 花國鋒 主持人 科技部 2019/08/01 2020/07/31
2019 益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發-益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發(2/2) 花國鋒 主持人 武敬和、游玉祥 科技部 2019/06/01 2020/05/31
2019 臺俄(RU)雙邊協議型擴充加值(add-on) 國際合作研究計畫-探討柳珊瑚多醣化學結構及NLRP3發炎體抑制活性(1/3) 花國鋒 主持人 科技部 2019/01/01 2021/12/31
2018 Identification and therapeutic approach of NLRP3 inflammasome inhibitors to treat diseases associated with neuroinflammation 花國鋒 主持人 安成生物科技股份有限公司 2018/12/01 2019/11/30
2018 LCHK168 對亨廷頓舞蹈症小鼠之影響 花國鋒 主持人 匯德生物科技股份有限公司 2018/10/01 2019/09/30
2018 LCHK168 對人類口腔癌之毒殺作用及作用機轉 花國鋒 主持人 匯德生物科技股份有限公司 2018/10/01 2019/09/30
2018 皿培牛樟芝生產技術改進及抗發炎活性之探討 花國鋒 主持人 睿森生物科技有限公司 2018/05/01 2018/10/31
2018 益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發-益生菌產製與人工合成抗菌胜肽於禽畜及伴侶動物保健用飼料添加物之功能驗證與開發(1/2) 鄭永祥 共同主持人 武敬和、花國鋒、游玉祥 科技部 2018/06/01 2019/05/31
2018 評估人蔘皂甙衍生物CLA-LCHK-168抑制NLRP3發炎體的效果 花國鋒 主持人 匯德生物科技股份有限公司 2018/05/01 2018/10/31
2017 HE-07Fr4對IgA腎炎小鼠腎臟纖維化及巨噬細胞NLRP3發炎體活化之影響 花國鋒 主持人 財團法人工業技術研究院 2017/05/12 2017/08/31
2017 以小鼠疾病模式探討人蔘皂苷預防與改善痛風性發炎之功效 花國鋒 主持人 匯德生物科技股份有限公司 2017/10/01 2018/09/30
2017 建置一台英雙方研究O-linked N-乙醯葡萄糖胺修飾蛋白調控NLRP3發炎體之整合型平台 ( 2 / 2 ) 花國鋒 主持人 吳世雄 羅禮強 朱俐潔 李佳陽 陳安 科技部 2017/04/01 2018/03/31
2017 牛樟芝產品提升免疫細胞殺菌功能之探討 花國鋒 主持人 睿森生物科技有限公司 2017/05/01 2017/10/31
2017 評估乙烯吡咯衍生物用於預防與改善痛風性發炎的可能性 花國鋒 主持人 匯德生物科技股份有限公司 2017/06/16 2017/11/15
2017 評估人蔘皂甙預防與改善痛風性發炎的效果 花國鋒 主持人 匯德生物科技股份有限公司 2017/05/01 2017/10/31
2016 IgA腎炎小鼠的腎臟白血球浸潤與細胞激素分泌 花國鋒 主持人 工業技術研究所 2016/07/04 2016/12/26
2016 低耗能養殖池底水力迴轉清淤臂的研發 花國鋒 主持人 睿森生物科技有限公司 2016/05/01 2016/10/31
2016 利用NLRP3發炎體為主之疾病專一性分析平台驗證人蔘皂苷對慢性腎臟病與代謝疾病預防與改善之功效 花國鋒 主持人 朱俐潔 科技部 2016/08/01 2019/07/31
2016 建置一台英雙方研究O-linked N-乙醯葡萄糖胺修飾蛋白調控NLRP3發炎體之整合型平台 花國鋒 主持人 吳世雄、羅禮強、朱俐潔、朱清良李、佳陽 科技部 2016/04/01 2017/03/31
2016 驗證人蔘皂苷對亨廷頓舞蹈症預防與改善之功效 花國鋒 主持人 匯德生物科技股份有限公司 2016/10/01 2017/09/30
2015 人蔘皂甙衍生物毒性與活性測試 花國鋒 主持人 匯德生物科技股份有限公司 2015/04/24 2015/09/23
2015 探討固態發酵培養牛樟芝產品預防與改善痛風的效果 花國鋒 主持人 睿森生物科技有限公司 2015/05/01 2015/10/31
2015 驗證人蔘皂苷對痛風預防與改善之功效 花國鋒 主持人 匯德生物科技股份有限公司 2015/05/01 2016/04/30
2014 人蔘皂苷免疫調節活性試驗 花國鋒 主持人 匯德生物科技股份有限公司 2014/05/01 2015/04/30
2014 台俄國合計畫-海洋天然物醫藥保健產品開發之合作交流平台 花國鋒 主持人 行政院國家科學委員會 2014/01/01 2016/12/31
2014 開發及生產行銷高經濟機能性生技產品(專案) 花國鋒 主持人 匯德生物科技股份有限公司 2014/05/01 2014/10/31
2014 開發及生產行銷高經濟機能性生技產品(專案) 花國鋒 主持人 睿森生物科技有限公司 2014/05/01 2014/10/31
2013 寶石珊瑚萃取物生技保養品之開發 邱奕志 協同主持人 陳怡伶、羅祺祥、花國鋒、曹博宏 明麗生技股份有限公司 2013/01/01 2013/12/31
2013 竹醋液與其活性成分在發炎與代謝相關疾病預防及改善之應用 花國鋒 主持人 行政院國家科學委員會 2013/08/01 2016/07/31
2012 新穎陽離子抗菌胜(宿主防禦胜)之抗菌、抗癌與抗發炎機制探討 陳威戎 共同主持人 陳怡伶、花國鋒 行政院國家科學委員會 2012/08/01 2013/07/31
2011 開發肉桂醛為預防發炎之保健產品與治療發炎相關疾病之輔助製劑 花國鋒 主持人 行政院國家科學委員會 2011/08/01 2012/07/31
2009 肝膿瘍性克雷伯氏肺炎桿菌莢膜多醣體結構與功能性分析 花國鋒 主持人 行政院國家科學委員會 2009/02/01 2010/07/31